Insight into Amyloid Formation Using Congo Red as the Electrochemical Probe
Identifieur interne : 001750 ( Main/Exploration ); précédent : 001749; suivant : 001751Insight into Amyloid Formation Using Congo Red as the Electrochemical Probe
Auteurs : Anthony J. Veloso [Canada] ; Tiffiny Chan [Canada] ; Vinci Wing Ze Ung [Canada] ; Leayen Lam [Canada] ; Kagan Kerman [Canada]Source :
- [ 1040-0397 ]
Abstract
The amyloid‐β (Aβ) aggregation pathway is an important target for the discovery of drugs that can prevent or delay the onset of Alzheimer’s disease (AD). The electrochemistry of Congo Red (CR) represents a particularly promising tool for screening of Aβ‐binding therapeutics in a rapid and cost‐effective format. The results of the differential pulse voltammetry (DPV) measurements were confirmed using simultaneous UV‐vis analysis of the same incubated Aβ samples. The early changes in the electrochemical signals were attributed to the interaction of the Aβ oligomers with CR. The electrochemical approach, in principle, allowed monitoring small molecule‐Aβ interactions on the time scale of aggregation.
Url:
DOI: 10.1002/elan.201100329
Affiliations:
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Veloso</name></author><author><name sortKey="Chan, Tiffiny" sort="Chan, Tiffiny" uniqKey="Chan T" first="Tiffiny" last="Chan">Tiffiny Chan</name></author><author><name sortKey="Wing Ze Ung, Vinci" sort="Wing Ze Ung, Vinci" uniqKey="Wing Ze Ung V" first="Vinci" last="Wing Ze Ung">Vinci Wing Ze Ung</name></author><author><name sortKey="Lam, Leayen" sort="Lam, Leayen" uniqKey="Lam L" first="Leayen" last="Lam">Leayen Lam</name></author><author><name sortKey="Kerman, Kagan" sort="Kerman, Kagan" uniqKey="Kerman K" first="Kagan" last="Kerman">Kagan Kerman</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:65EB9F69D5D1EAB9DCF2E919354D822DC555B7C4</idno><date when="2011" year="2011">2011</date><idno type="doi">10.1002/elan.201100329</idno><idno type="url">https://api-v5.istex.fr/document/65EB9F69D5D1EAB9DCF2E919354D822DC555B7C4/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001464</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001464</idno><idno type="wicri:Area/Istex/Curation">001464</idno><idno type="wicri:Area/Istex/Checkpoint">000333</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000333</idno><idno type="wicri:doubleKey">1040-0397:2011:Veloso A:insight:into:amyloid</idno><idno type="wicri:Area/Main/Merge">001826</idno><idno type="wicri:Area/Main/Curation">001750</idno><idno type="wicri:Area/Main/Exploration">001750</idno></publicationStmt><sourceDesc><biblStruct><analytic><author><name sortKey="Veloso, Anthony J" sort="Veloso, Anthony J" uniqKey="Veloso A" first="Anthony J." last="Veloso">Anthony J. 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The electrochemistry of Congo Red (CR) represents a particularly promising tool for screening of Aβ‐binding therapeutics in a rapid and cost‐effective format. The results of the differential pulse voltammetry (DPV) measurements were confirmed using simultaneous UV‐vis analysis of the same incubated Aβ samples. The early changes in the electrochemical signals were attributed to the interaction of the Aβ oligomers with CR. The electrochemical approach, in principle, allowed monitoring small molecule‐Aβ interactions on the time scale of aggregation.</div></front></TEI><affiliations><list><country><li>Canada</li></country></list><tree><country name="Canada"><noRegion><name sortKey="Veloso, Anthony J" sort="Veloso, Anthony J" uniqKey="Veloso A" first="Anthony J." last="Veloso">Anthony J. Veloso</name></noRegion><name sortKey="Chan, Tiffiny" sort="Chan, Tiffiny" uniqKey="Chan T" first="Tiffiny" last="Chan">Tiffiny Chan</name><name sortKey="Kerman, Kagan" sort="Kerman, Kagan" uniqKey="Kerman K" first="Kagan" last="Kerman">Kagan Kerman</name><name sortKey="Kerman, Kagan" sort="Kerman, Kagan" uniqKey="Kerman K" first="Kagan" last="Kerman">Kagan Kerman</name><name sortKey="Lam, Leayen" sort="Lam, Leayen" uniqKey="Lam L" first="Leayen" last="Lam">Leayen Lam</name><name sortKey="Wing Ze Ung, Vinci" sort="Wing Ze Ung, Vinci" uniqKey="Wing Ze Ung V" first="Vinci" last="Wing Ze Ung">Vinci Wing Ze Ung</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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